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Glutamate dehydrogenase (gldh, gdh) is an enzyme observed in both prokaryotes and eukaryotic mitochondria Gdh activity is strictly regulated by a variety of allosteric compounds. The aforementioned reaction also yields ammonia, which in eukaryotes is canonically processed as a substrate in the urea cycle.
It is found in all living organisms serving both catabolic and anabolic reactions. It is located at the intersection of multiple metabolic pathways and participates in a variety of cellular activities Glutamate dehydrogenase (gdh) is an enzyme found within the mitochondria of cells, structures central to energy production
Gdh exists at a crossroads between the metabolism of amino acids and carbohydrates, facilitating a reaction that connects these two major metabolic pathways.
Gdh is found in all organisms, but in animals is allosterically regulated by a wide array of metabolites. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. Glutamate dehydrogenase (gdh) is a key enzyme in mammalian glutamate metabolism
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