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Authors note that tumors likely employ a variety of strategies to evade immune detection Discover how cancer cells bypass immune defenses and explore innovative strategies to combat the disease through scientific insights and therapeutic approaches. But the discovery could lead to a new approach for targeted cancer therapies.
By activating an immune signaling pathway inside cancer cells, mit researchers found a way to force tumors to produce a molecule that leads to their own destruction. A new study shows that tumors not only evade the immune system but can actively reprogram immune cells to stop fighting. By blocking the interactions between checkpoint receptors and their ligands, the lymphocytes can avoid inactivation and effectively target the cancer cells.
Cancer immunotherapy stalled for decades until the discovery and characterization of negative regulators of immune activation—immune checkpoints, which were found to be hijacked by tumor cells to escape immune surveillance.
This review systematically describes the immune checkpoints that function on various types of immune cells, as well as their molecular structure and functional diversity, and elucidates their role in achieving tumor immune escape. Research led by the chiba cancer center research institute in japan has discovered a surprising way cancer evades the immune system It essentially hacks the immune cells, transferring its own.
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