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First of all, we need to identify the problem. 在大多数情况下，"first" 和 "firstly" 可以互换使用，但 "firstly" 通常用于强调某件事是最重要的。 At the first time：它是一个介词短语，在句子中常作时间状语，用来指在某个特定的时间点第一次发生的事情。 例如，“At the first time I met you, my heart told me that you are the one.”（第一次见到你的时候，我的心就告诉我，你就是那个人。 first 有多种词性，其中就有名词，剑桥词典对作名词的first的定义是：the first person or thing to do or be something, or the first person or thing mentioned，例句有： [ + to infinitive ] She was one of the first to arrive.和He is the first (= very willing) to admit that much of his success is due to his good looks.

first和firstly作副词时完全同义，都可以表示“第一，首先”，都可用作句子副词，此时first也可写作first of all。 例如： First，I would like to thank everyone for coming. 首先，我要感谢各位光临。 Firstly，I would like to thank everyone who has contributed to this success. 要创建一个新的参考文献标题，请使用以下命令:1.在菜单栏“搜索”中输入关键字并搜索关键词,如"The Endnote Text"或"the first endnoting manualizations",查找有关的参考资料信息。 Last name 和 First name 到底哪个是名哪个是姓？ 上学的时候老师说因为英语文化中名在前，姓在后，所以Last name是姓，first name是名，假设一个中国人叫孙悟空，那么他的first nam… 显示全部 关注者 460

“First in Class”，顾名思义，也就是首创新药。 根据FDA定义，被授予First-in-class的药物是指使用全新的、独特的作用机制来治疗某种疾病的药物。 它是一种彻底创新的方法，第一个能够治疗该疾病的药。 在NMPA的申报当中，它同样也应该属于1.1类新药。

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