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View all family and domain features for this entry's canonical sequence in the uniparc feature viewer Human ortholog (s) of this gene implicated in neural tube defect. Search… there are 8 potential isoforms mapped to this entry
Showing features for compositional bias Is expressed in anterior neural tube and optic cup Mthfd1l (methylenetetrahydrofolate dehydrogenase (nadp+ dependent) 1 like) is a protein coding gene
Diseases associated with mthfd1l include colon adenocarcinoma and adenocarcinoma.
In contrast to mthfd1 that has trifunctional methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetase enzymatic activities, mthfd1l only has formyltetrahydrofolate synthetase activity. (2003) determined that the mthfd1l gene spans 236 kb and has 28 exons plus an alternative exon, 8a Mthfd1l (hgnc symbol) this gene has proteins that correspond to the following uniprotkb identifiers This gene is a member of the human ccds set
Entries removed from unreviewed uniprotkb/trembl will remain accessible in the uniparc sequence archive Please read our help page, view affected entries and proteomes, or contact us with any questions Mthfd1l enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine Predicted to be active in cytosol
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