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Androgen insensitivity syndrome (ais) is a rare, inherited, sexual development disorder It results from alterations in the androgen receptor gene, leading to a frame of hormonal resistance, which may present. People with ais are genetically male, but don’t develop male external genitals because their bodies can’t respond to male sex hormones
Ais can cause problems during puberty, as well as infertility as an adult Androgenic insensitivity syndrome is the most common cause of disorders of sexual differentiation in 46,xy individuals Contents what is androgen insensitivity syndrome?
Ais results when the function of the androgen receptor (ar) is impaired
The ar protein (pictured) mediates the effects of androgens in the human body Androgen insensitivity syndrome (ais) is a condition involving the inability to respond to androgens, typically due to androgen receptor dysfunction Androgen insensitivity syndrome (ais) is typically characterized by evidence of feminization (i.e., undermasculinization) of the external genitalia at birth, abnormal secondary sexual development in puberty, and infertility in individuals with a 46,xy karyotype. In people with androgen insensitivity syndrome, the body's cells and tissues are unable to respond to certain male sex hormones (called androgens) that are important for normal male sexual development before birth and during puberty.
Androgen insensitivity is an umbrella term for a number of genetic conditions where the body does not respond appropriately to testosterone and other androgens There are multiple causes of androgen insensitivity syndromes (ais). Androgen insensitivity syndrome (ais) affects the development of a person's genitals and reproductive organs The 2 types of ais are called complete androgen insensitivity syndrome (cais) and partial androgen insensitivity syndrome (pais).
Androgen insensitivity syndrome (ais) is when a person who has one x and one y chromosome (typically seen in males) is resistant to hormones that produce a male appearance (called androgens)
As a result, the person has some of the physical traits of a female, but the genetic makeup of a male. Androgen insensitivity syndrome is a genetic condition which affects a child’s sexual development before birth and during puberty Learn about the signs and symptoms of androgen insensitivity syndrome, what causes it, and how it's diagnosed and treated at chop.
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