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胰腺癌、肝胆系癌、胃癌、 结直肠癌 的CA19-9水平分别是正常均值的683、535、279、115倍。 而 阳性 率以胰腺癌为最高，故CA19-9是胰腺癌较好的标志。 临床上常用的与胰腺癌诊断相关肿瘤标志物有糖类抗原19-9（CA19-9）、 癌胚抗原 （CEA）、糖类抗原125（CA125）等，其中CA19-9是胰腺癌中应用价值最高的肿瘤标志物，可用于辅助诊断、疗效监测和复发监测。 糖类抗原19-9（CA19-9） CA19-9是胰腺癌，胃癌，结、直肠癌、胆囊癌的相关标志物，大量研究证明CA19-9浓度与这些肿瘤大小有关，是至今报道的对胰腺癌敏感性最高的标志物。
肿瘤标志物是肿瘤筛查的重要手段，而越来越多的人因体检发现肿瘤标志物异常而不知所措。 其中糖类抗原19-9（CA19-9）是胰腺癌最重要的肿瘤标志物，那么，我们应该如何解读CA19-9升高？ 又该如何应对呢？ 癌抗原19-9（CA19-9）是一种与胰腺癌、胆囊癌、结肠癌和胃癌等恶性肿瘤相关的肿瘤标志物，又称胃肠道相关抗原，属于肿瘤标志物分类。 对胰腺癌的诊断灵敏度为85%-95%，且术后水平可随病情好转降低。 CA19-9 是检测胰腺癌的常用肿瘤标志物，对胰腺癌辅助诊断、预后评估、疗效和复发监测有一定价值，但在某些良性疾病中也会升高，需注意鉴别。
CA19-9即糖类抗原19-9，是一个肿瘤指标，其正常值＜37 u/ml。 如果CA19-9轻度升高，如升高1-2倍，值也＜100 u/ml，多见于炎症，如消化道炎症，包括肝脏炎症、胆道炎症、胰腺炎症。
通常认为，血清CA19-9的正常参考值为 0-37 U/mL （不同检测机构可能略有差异）。 轻度升高（如37-100 U/mL） 可能见于良性病变（如胆管炎、胰腺炎），而 显著升高（如超过1000 U/mL） 需警惕恶性肿瘤可能，但最终确诊需结合影像学、病理等检查。 CA19-9与多种恶性肿瘤有关，尤其是 胰腺癌 和 胆管癌，在这些癌症的患者中，血清CA19-9水平通常会明显升高。 此外， 胃癌 、 结直肠癌 、 肝癌 、 胆囊癌 等消化道恶性肿瘤也可能导致CA19-9的升高。 It is also a tumor marker used primarily in the management of pancreatic cancer
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